Lucia Anguissola, (* between 1537 and 1542 in Cremona; 1565 probably in Cremona) was an Italian painter.
She was the sister of Sofonisba Anguissola. Her works reveal a clear influence from her older sister, who was probably also her teacher. When Giorgio Vasari visited the family in 1566, Lucia had already died.
Lucia mainly painted portraits. The few signed works were accompanied by a few other works that were sometimes attributed to her sister Sofonisba.